Table 5. Stratification analysis of association between the MKK7 p.Glu116Lys genotypes and lung cancer prognosis by selected variables.
| Variables | Glu/Glu genotype | Lys/Lys+Lys/Glu genotypes | Adjusted HR (95% CI) a | P homo b | P inter c | ||
|---|---|---|---|---|---|---|---|
| Patients. n | Death. n(%) | Patients. n | Death. n(%) | ||||
| Age (years) | 0.641 | 0.791 | |||||
| ≤ 60 | 1345 | 1018(75.7) | 125 | 97(77.6) | 1.51(1.23–1.87) | ||
| > 60 | 1323 | 1065(80.5) | 113 | 99(87.6) | 1.62(1.31–1.99) | ||
| Sex | 0.090 | 0.109 | |||||
| Male | 1916 | 1501(78.3) | 154 | 129(83.8) | 1.68(1.40–2.02) | ||
| Female | 752 | 582(77.4) | 84 | 67(79.8) | 1.28(0.99–1.65) | ||
| Family history of cancer | 0.595 | 0.229 | |||||
| No | 2453 | 1925(78.5) | 220 | 184(83.6) | 1.56(1.34–1.82) | ||
| Yes | 215 | 158(73.5) | 18 | 12(66.7) | 1.32(0.73–2.41) | ||
| Family history of lung cancer | 0.448 | 0.255 | |||||
| No | 2587 | 2026(78.3) | 231 | 192(83.1) | 1.55(1.34–1.80) | ||
| Yes | 81 | 57(70.4) | 7 | 4(57.1) | 1.03(0.36–2.91) | ||
| Smoking status | 0.261 | 0.178 | |||||
| Never | 1169 | 907(77.6) | 113 | 92(81.4) | 1.40(1.13–1.74) | ||
| Ever | 1499 | 1176(78.5) | 125 | 104(83.2) | 1.66(1.35–2.03) | ||
| Drinking status | 0.188 | 0.148 | |||||
| Never | 2168 | 1691(78.0) | 197 | 161(81.7) | 1.48(1.26–1.74) | ||
| Ever | 500 | 392(78.4) | 41 | 35(85.4) | 1.92(1.35–2.73) | ||
| Surgery | 0.584 | 0.522 | |||||
| No | 1665 | 1319(79.2) | 132 | 108(81.8) | 1.49(1.22–1.82) | ||
| Yes | 1003 | 764(76.2) | 106 | 88(83.0) | 1.62(1.30–2.03) | ||
| Chemotherapy | 0.837 | 0.848 | |||||
| No | 938 | 778(82.9) | 84 | 75(89.3) | 1.53(1.20–1.95) | ||
| Yes | 1730 | 1305(75.4) | 154 | 121(78.6) | 1.58(1.31–1.90) | ||
| Radiotherapy | 0.157 | 0.357 | |||||
| No | 1375 | 1041(75.7) | 124 | 95(76.6) | 1.38(1.12–1.71) | ||
| Yes | 1293 | 1042(80.6) | 114 | 101(88.6) | 1.71(1.39–2.11) | ||
| Histological types | 0.290 | 0.450 | |||||
| Adenocarcinoma | 1230 | 923(75.0) | 121 | 92(76.0) | 1.30(1.05–1.62) | ||
| Squamous cell carcinoma | 812 | 652(80.3) | 77 | 68(88.3) | 1.71(1.33–2.20) | ||
| Large cell carcinoma | 104 | 84(80.8) | 4 | 4(100.0) | 2.67(0.90–7.90) | ||
| Small cell lung cancer | 321 | 268(83.5) | 20 | 18(90.0) | 1.92(1.18–3.12) | ||
| Other d | 201 | 156(77.6) | 16 | 14(87.5) | 1.75(0.99–3.10) | ||
| Population sources | 0.769 | 0.803 | |||||
| Guangzhou | 1478 | 1190(80.5) | 133 | 118(88.7) | 1.52(1.26–1.84) | ||
| Suzhou | 1190 | 893(75.0) | 105 | 78(74.3) | 1.59(1.26–2.01) | ||
| Stages | 0.019 | 0.039 | |||||
| I+II | 564 | 392(69.5) | 42 | 31(73.8) | 1.12(0.77–1.62) | ||
| III | 871 | 697(80.0) | 70 | 59(84.3) | 1.31(1.00–1.71) | ||
| IV | 1233 | 994(80.6) | 126 | 106(84.1) | 1.88(1.53–2.30) | ||
| Nodal metastasis | 0.966 | 0.282 | |||||
| 0 | 640 | 436(68.1) | 44 | 29(65.9) | 1.52(1.04–2.23) | ||
| 1 | 559 | 436(78.0) | 58 | 47(81.0) | 1.38(1.02–1.88) | ||
| 2 | 893 | 738(82.6) | 69 | 59(85.5) | 1.50(1.15–1.97) | ||
| 3 | 576 | 473(82.1) | 67 | 61(91.0) | 1.52(1.15–1.99) | ||
| Distal metastasis | 0.010 | 0.088 | |||||
| 0 | 1435 | 1089(75.9) | 112 | 90(80.4) | 1.26(1.01–1.57) | ||
| 1 | 1233 | 994(80.6) | 126 | 106(84.1) | 1.88(1.53–2.30) | ||
| Metastasis | 0.555 | 0.282 | |||||
| No | 440 | 291(66.1) | 26 | 18(69.2) | 1.30(0.79–2.13) | ||
| Yes | 2228 | 1792(80.4) | 212 | 178(84.0) | 1.52(1.30–1.77) | ||
Bold type: statistically significant, P < 0.05.
a HRs were adjusted for age, smoking, stage, histology, surgery, chemo-therapy, and radio therapy status in a Cox regression model.
b P value of homogeneity test between strata for the related ORs of p.Glu116Lys (Lys/Lys+Lys/Glu vs. Glu/Glu genotype).
c P value of test for the multiplicative interaction between p.Glu116Lys genotypes and selected variables on cancer death in Cox regression models.
d Mixed-cell or undifferentiated carcinoma.