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. 2016 Mar 30;11(3):e0150271. doi: 10.1371/journal.pone.0150271

Fig 4. H&E stains of orthotopic tumors formed in athymic mice, showing hallmark characteristics of GBMs.

Fig 4

(A and B) All of the lines showed diffuse invasion of normal parenchymal. The hallmark features of glioblastoma were identified in the brains of mice injected with oncosphere lines, including increased mitotic activity (C, arrows), necrosis (D, designated “N”), and vascular proliferation (E, arrows). The oncosphere lines also demonstrated other histologic features specific to invasive gliomas, including spread through white matter tracts (F), neuronal satellitosis (G), and subventricular tumor formation (H). Original magnification for panel A was 25x; for F and H, 50x; for B and D, 100x; and for C, E, and G, 200x.