Table 3.

Metabolites significantly associated with annual eGFRcr change and incident CKD in the KORA study between visits S4 and F4

Metabolite	Annual eGFRcr Change			Incident CKD (n=95 cases)
	n	Direction	P Value	n	Direction	P Value
C-mannosyltryptophan	985	+	8.7E-06	920	+	1.1E-03
Pseudouridine	989	+	1.3E-05	924	+	3.7E-03
O-sulfo-L-tyrosine	987	+	6.8E-05	922	+	1.4E-02

A positive direction in eGFRcr change denotes a decline of kidney function over time per unit increase in metabolite concentration and a positive association with incident CKD with higher odds of CKD. For the analysis of incident CKD, patients with CKD at the S4 visit had been excluded (see the Concise Methods). Pairwise metabolite Pearson’s correlation coefficients in the eGFRcr change sample were 0.74 (C-mannosyl-tryptophan, pseudouridine), 0.41 (C-mannosyltryptophan, O-sulfo-L-tyrosine), and 0.46 (pseudouridine, O-sulfo-L-tyrosine). Mean eGFRcr among those who developed incident CKD was 73.4 (SD 9.5) at the S4 visit and 51.7 (SD 8.4) at the F4 follow-up visit.