Figure 1.

Cisplatin model shows physiologic evidence of chronic renal failure at 9 weeks. (A) Mice treated with two doses of cisplatin (n=4) showed significant (P<0.01) decreases in GFR starting at 4 weeks relative to controls (n=4). GFR remained low at 9 weeks after cisplatin (7 weeks after second dose). (B) Correspondingly, plasma creatinine remained markedly increased relative to controls (*P< 0.01) both at 9 weeks and up to 25 weeks after cisplatin administration, indicating chronic renal failure. Error bars, ±SEM.