Effects of partial dopamine depletion of the striatum on visual discrimination learning. (A) Number of trials required to reach visual discrimination criterion. (B) Response accuracies plotted for vehicle- and 6-OHDA-infused animals show learning impairments following partial dopamine depletion. 6-OHDA manipulation dramatically increased (C) errors to criterion and (D) total omissions in both BDNF+/+ and BDNF+/− mice. All data are Mean±SEM. (*, ** p<0.05, 0.01 main effect of 6-OHDA manipulation; #, ##, ### p<0.05, 0.01, 0.001 post hoc comparisons vs vehicle-infused mice for the corresponding testing day).