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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2016 Feb 10;233(8):1361–1375. doi: 10.1007/s00213-016-4229-6

Figure 6.

Figure 6

Amperometric measurements of depolarization-evoked glutamate release. (A) Representative traces depicting glutamate spikes following terminal depolarization by local application of potassium in the dorsal striatum of control and dopamine-depleted BDNF+/+ and BDNF+/− mice. (B) Bar charts show reduced glutamate signal amplitudes in BDNF mutants that previously received vehicle infusions. However, potassium-elicited glutamate release remained significantly higher in 6-OHDA-infused BDNF+/− mice as compared to vehicle-infused BDNF+/− mice indicating that partial depletion of dopamine normalized the effect of genotype on glutamatergic transmission. (* p<0.01 vs vehicle-infused BDNF+/+ mice; # 0.01 vs 6-OHDA-infused BDNF+/− mice; all post hoc comparisons).