Skip to main content
. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Acta Physiol (Oxf). 2015 Dec 29;217(1):80–93. doi: 10.1111/apha.12637

Figure 3). PPADS, but not MRS2179, into the RTN reduced the effect of hypercapnia on breathing in awake rats.

Figure 3)

Changes in (A) tidal volume (VT, ml/kg), (B) respiratory frequency (fR, breaths/min), (C) minute volume (VE, ml/kg/min), (D) mean arterial pressure (MAP, mmHg) and (E) heart rate (HR, bpm) elicited by hypercapnia (7% CO2) in animals that received saline, PPADS or MRS2179 injections into the RTN. F) Photomicrograph of a coronal section showing bilateral injections in the RTN and the computer-assisted plots of the center of the injection sites revealed by the presence of dye (coronal projection on plane Bregma −11.6 mm of the Paxinos atlas (Paxinos & Watson, 1998)). Abbreviations: py, pyramidal tract; Sp5, spinal trigeminal tract; 7, facial motor nucleus. Arrows indicate injection sites. Black dots represent the injections sites into the RTN and white dots represents the misplaced injections. Scale bar is 1 mm. *different from saline; (p < 0.05); n = 5-10/group of rats.

HHS Vulnerability Disclosure