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. 2016 Mar 31;7:426. doi: 10.3389/fmicb.2016.00426

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Copyright © 2016 Derakhshani, De Buck, Mortier, Barkema, Krause and Khafipour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentiation of functional metagenomes of ileal mucosa (MAM) and fecal microbiota in control and MAP-infected calves. A Statistical differences between KEGG pathways (explored at Levels 1–3, indicated as L1–L3) of ileal MAM metagenomes were evaluated by LEfSe, a metagenome analysis approach which performed the linear discriminant analysis following the Wilcoxon Mann–Whitney test to assess effect size of each differentially abundant variable. The length of the horizontal bars indicated log-fold changes for each variable. Color code represents the class of treatment (red indicates variables that were significantly altered in response to MAP infection, whereas green indicates variables that were significantly associated with the control group).