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. 2016 Feb 17;30(4):455–468. doi: 10.1210/me.2015-1147

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Figure 7. — MAPK signaling from the OXTR is mediated by GRK6. A, HEK-293 cells expressing the OXTR and treated with siRNA directed against GRK6 demonstrated a significant decrease in maximal pERK signaling at 2, 5, 10, and 30 minutes (*, P < .0001). Two-way ANOVA demonstrated that the 2 curves differed significantly (P < .0001). B, There were no differences in the pERK signal between cells treated with CTL siRNA and siRNA directed against GRK5 (P = .28). C, Cells treated with siRNA directed against GRK2 demonstrated significantly enhanced pERK expression at 2, 5, 30, and 60 minutes compared with cells treated with CTL siRNA (*, P < .0001) (C). Two-way ANOVA demonstrated that the 2 curves differed significantly (P < .0001).