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. 2016 Mar 31;10:96. doi: 10.3389/fnins.2016.00096

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Copyright © 2016 Raphan, Cohen, Xiang and Yakushin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model predictions of the differential effects on the systolic to diastolic transitions as a function of time due to transient changes in Desired PB and Threshold (T). (A) Changes in Desired BP simulated the anticompensatory behavior of BP and HR during a VVR with drops in BP, Systolic BP, Pulse Pressure, and HR. (B) Changes in Threshold generate drops in HR, with increases in time between systoles (R-R interval). During the transient change in Threshold, there were large increases in Systolic BP and pulse pressure, not consistent with a VVR.