Table 3.

A selection of proteins identified in EVs isolated from cultured cell media (neurons, astrocytes, microglia, oligodendrocytes) and CSF that are relevant for the CNS under physiological and pathological conditions.

Gene	Protein name	Na	Ab	Mc	Od	CSF	Referencese
ANG	Angiogenin					X	Chiasserini et al., 2014
APOE	Apolipoprotein E	X				X	Harrington et al., 2009; Marimpietri et al., 2013
APP	Amyloid beta A4 protein	X		X		X	Rajendran et al., 2006; Harrington et al., 2009; Joshi et al., 2014
CD13	Aminopeptidase N			X			Potolicchio et al., 2005
CP	Ceruloplasmin	X				X	Faure et al., 2006; Chiasserini et al., 2014
CNP	2′,3′-cyclic-nucleotide 3'-phosphodiesterase	X			X	X	Kramer-Albers et al., 2007; Marimpietri et al., 2013; Chiasserini et al., 2014
EAAT1	Excitatory amino acid transporter 1	X					Faure et al., 2006
GRIA2	Glutamate receptor 2	X					Faure et al., 2006
GRIA3	Glutamate receptor 3	X					Faure et al., 2006
GRIA4	Glutamate receptor 4					X	Chiasserini et al., 2014
HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1					X	Chiasserini et al., 2014; Keerthikumar et al., 2015a
IL1B	Interleukin-1 beta			X			Bianco et al., 2005
MBP	Myelin basic protein				X	X	Kramer-Albers et al., 2007; Chiasserini et al., 2014
MCT1	Monocarboxylate transporter 1	X		X			Potolicchio et al., 2005; Marimpietri et al., 2013
MMP2	Matrix metallopeptidase-2		X			X	Sbai et al., 2010; Chiasserini et al., 2014
MMP9	Matrix metallopeptidase-9		X				Sbai et al., 2010
MOG	Myelin oligodendrocyte glycoprotein				X	X	Kramer-Albers et al., 2007; Chiasserini et al., 2014
NEFL	Neurofilament light polypeptide					X	Chiasserini et al., 2014
NEFM	Neurofilament medium polypeptide					X	Harrington et al., 2009
PAR4	Prostate apoptosis response 4 protein (PAR-4)		X				Wang et al., 2012
PARK7	Protein deglycase DJ-1					X	Chiasserini et al., 2014
PFN1	Profilin-1					X	Chiasserini et al., 2014
PLP1	Myelin proteolipid protein				X	X	Kramer-Albers et al., 2007; Chiasserini et al., 2014
PPIA	Peptidyl-prolyl cis-trans isomerase A (Cyclophilin A)	X	Xf	X	X	X	Potolicchio et al., 2005; Faure et al., 2006; Kramer-Albers et al., 2007; Chiasserini et al., 2014
PRNP	Prion protein	X				X	Faure et al., 2006; Vella et al., 2008a
SOD1	Superoxide dismutase [Cu-Zn]	Xg	Xg			X	Gomes et al., 2007; Basso et al., 2013; Chiasserini et al., 2014
SNCA	Alpha-synuclein	X					Emmanouilidou et al., 2010
SYN1	Synapsin-1		X			X	Wang et al., 2011; Chiasserini et al., 2014
MAPT	Microtubule-associated protein tau	Xh		X		Xi	Saman et al., 2012; Asai et al., 2015
TARDBP	TAR DNA-binding protein 43 (TDP-43)	X					Nonaka et al., 2013
TUBA4A	Tubulin alpha-4A chain	X				X	Chiasserini et al., 2014; Keerthikumar et al., 2015a
VCP	Valosin-containing protein	X	X			X	Basso et al., 2013; Chiasserini et al., 2014; Keerthikumar et al., 2015a
VEGFA	Vascular endothelial growth factor A	X	X				Schiera et al., 2007; Proia et al., 2008

^aN, neuronal cells (primary cultures or cell lines).

^bA, astrocytes.

^cM, microglia.

^dO, oligodendrocytes.

^eReferences, the first published evidence.

^fUnpublished evidence.

^gDetected wild-type and mutant SOD1.

^hDetected tau and phosphorylated tau.

ⁱDetected only phosphorylated tau.