Table III.
The selected clinical parameters in patients with colorectal cancer compared to different polymorphic variants of the MDR1 gene
| Parameter | C3435T polymorphism | G2677T/A polymorphism | ||||||
|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | Value of p | GG | GT | TT | Value of p | |
| Gender: Male Female |
10 7 |
31 22 |
19 18 |
0.77 |
21 18 |
31 23 |
8 4 |
0.73 |
| Age [years]: Mean Range |
73 57–82 |
68 54–81 |
79 68–-83 |
0.013 |
73 57–82 |
69 54–83 |
73 65–80 |
0.40 |
| pT Tis T1 T2 T3 T4 |
0 0 1 7 2 |
2 0 2 22 7 |
0 0 2 5 3 |
0.64 |
0 0 2 12 4 |
2 0 3 18 6 |
0 0 0 3 2 |
0.92 |
| pN N0 N1 N2 |
5 2 2 |
16 10 7 |
7 2 1 |
0.80 |
8 5 4 |
18 6 5 |
1 3 1 |
0.50 |
| M M0 M1 |
8 1 |
23 9 |
9 0 |
0.14 |
15 1 |
22 6 |
3 2 |
0.20 |
| Location: Colon ascedens Colon transverses Colon descedens Colon sigmoideum Rectum |
2 1 0 1 6 |
6 6 3 15 3 |
3 2 1 3 0 |
0.10 |
3 2 2 6 5 |
7 5 2 12 3 |
1 2 0 1 1 |
0.86 |
| Histological type: Adenocarcinoma Others |
9 1 |
32 1 |
9 1 |
0.48 |
17 1 |
27 2 |
5 0 |
0.81 |
| Degree of differentiation: G1 G2 G3 |
0 8 1 |
4 26 2 |
1 8 0 |
0.72 |
2 15 0 |
3 22 2 |
0 4 1 |
0.56 |
| Symptoms of anaemia: No Yes |
5 5 |
8 25 |
2 8 |
0.07 |
7 11 |
6 23 |
2 3 |
0.52 |
| Body weight loss: No Yes |
5 5 |
14 19 |
6 4 |
0.79 |
11 7 |
12 17 |
1 4 |
0.28 |
| Obstruction: No Yes |
7 3 |
18 15 |
7 3 |
0.72 |
9 9 |
20 9 |
3 2 |
0.33 |
| Radical surgery: No Yes |
2 8 |
6 27 |
1 9 |
0.82 |
3 15 |
4 25 |
1 4 |
0.89 |
TNM classification of malignant tumours (T – size or direct extent of the primary tumour (Tis: carcinoma in situ; T0: no signs of tumour; T1, T2, T3, T4: size and/or extension of the primary tumour), N – degree of spread to regional lymph nodes (N0: tumour cells absent from regional lymph nodes; N1: regional lymph node metastasis present; N2: tumour spread to an extent between N1 and N3), M – presence of distant metastasis (M0: no distant metastasis, M1: metastasis to distant organs)).