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. 2016 Mar 31;7:431. doi: 10.3389/fmicb.2016.00431

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Copyright © 2016 Thiaville, Frelin, García-Salinas, Harrison, Hasnain, Horenstein, Díaz de la Garza, Henry, Hanson and de Crécy-Lagard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model-predicted changes in the concentrations of folates and their precursors in response to overexpression of PanB. (A) The response when only the V_max of the PanB folate-cleaving reaction is increased, leaving other model parameters the same. (B) The response when both the PanB V_max and the external flux into 6-hydroxymethyldihydropterin are increased at the same time.