Table 1.
Summary statistics of meta-analyses comparing outcomes of liver resection with BDTT and NBDTT
| Outcome measure (Number of studies) |
n (%)/or Mean (SD) |
Heterogeneity X2 (p) I2 | OR/MD (95% CI) | p | |
|---|---|---|---|---|---|
| BDTT n = 281 | NBDT n = 5770 | ||||
| Blood loss (mls) (n = 4) | 1500 (870) | 1300 (800) | 0.96 (0.81) 0% | 15.15 [−0.38, 30.68] | 0.060 |
| Duration of Surgery (mins) (n = 3) | 425 (79) | 375 (90) | 3.44 (0.18) 42% | 65.78 [24.48, 107.07] | 0.002 |
| Positive margin (n = 4) | 31 (24%) | 400 (25%) | 0.28 (5.49) 45% | 1.10 [0.51, 2.37] | 0.810 |
| UICC Stage III/IV (n = 5) | 99 (75%) | 1717 (45%) | 19.47 (0.006)79% | 4.18 [1.42, 12.29] | 0.009 |
| Tumour size (cm) (n = 6) | 5.4 (6.8) | 5.6 (3.5) | 104.14 (<0.00001), 92% | −0.30 [−1.09, 0.49] | 0.450 |
| Poor Differentiation (n = 7) | 95 (48%) | 1167 (34%) | 10.00 (<0.12), 40% | 1.88 [1.15, 3.05] | 0.010 |
| Tumour encapsulation (n = 6) | 46 (30%) | 903 (38%) | 13.15 (0.02), 62% | 0.78 [0.39, 1.56] | 0.480 |
| Lymphovascular invasion (n = 10) | 149 (61%) | 1404 (26%) | 28.21 (0.009), 68% | 4.85 [2.73, 8.61] | <0.001 |
| Macrovascular invasion (n = 10) | 97 (40%) | 803 (15%) | 8.73 (0.46), 0% | 5.31 [3.87, 7.28] | <0.001 |
| Hospital stay (days) (n = 3) | 22 (3.8) | 17 (6.3) | 2.26 (0.32) 11% | 1.05 [0.53, 1.56] | <0.001 |
| Morbidity (n = 3) | 39 (35%) | 309 (31%) | 6.59 (0.04), 70% | 1.17 [0.55, 2.50] | 0.680 |
| Mortality (n = 6) | 5 (3%) | 63 (0.1%) | 4.56 (0.21), 34% | 1.43 [0.40, 5.17] | 0.580 |
| 1 Year survival (n = 7) | 121 (72%) | 3129 (81%) | 10.09 (0.12), 41% | 0.54 [0.33, 0.88] | 0.010 |
| 3 Year survival (n = 8) | 74 (40%) | 1787 (55%) | 18.02 (0.01), 61% | 0.54 [0.31, 0.94] | 0.030 |
| 5 year survival (n = 8) | 35 (16%) | 1876 (45%) | 29.87 (<0.0001), 77% | 0.25 [0.10, 0.63] | 0.003 |
UICC, union for international cancer control; BDTT, bile duct tumour thrombus; NBDT, no bile duct tumour thrombus; OR, odds ratio; MD, mean difference; CI, confidence interval.