Table 1.
Baseline and intra-operative characteristics of patients with and without perioperative transfusion for perihilar cholangiocarcinoma. Variables are expressed as numbers (count) and percentages, unless stated otherwise
| Variable | Total (N = 145) | No transfusion N = 65 | Transfusion N = 80 | P-valuea |
|---|---|---|---|---|
| Age (years), mean (sd) | 63 ± 11.1 | 66 ± 10.7 | 59 ± 10.7 | 0.001 |
| Sex | 0.108 | |||
| Female | 56 | 21 (37.5) | 35 (62.5) | |
| Male | 89 | 44 (49.4) | 45 (50.6) | |
| ASA classification | 0.389 | |||
| 1–2 | 126 | 54 (42.9) | 72 (57.1) | |
| 3 | 16 | 8 (50.0) | 8 (50.0) | |
| Jaundice at presentation | 0.050 | |||
| No | 30 | 18 (60.0) | 12 (40.0) | |
| Yes | 112 | 46 (41.1) | 66 (58.9) | |
| Preoperative biliary drainage | 0.074 | |||
| No | 19 | 11 (57.9) | 8 (42.1) | |
| Percutaneous | 5 | 1 (20.0) | 4 (80.0) | |
| Endoscopic | 89 | 44 (49.4) | 45 (50.6) | |
| Both | 32 | 9 (28.1) | 23 (71.9) | |
| Preoperative cholangitis | 0.012 | |||
| No | 105 | 55 (52.4) | 50 (47.6) | |
| Yes | 27 | 7 (25.9) | 20 (74.1) | |
| Preoperative total bilirubin (μmol/L), median (IQR) | 14 ± 8 | 11 ± 10 | 19 ± 28 | 0.488 |
| Preoperative hemoglobin, mean (sd) | 7.9 ± 1.1 | 8.0 ± 1.0 | 7.8 ± 1.1 | 0.197 |
| Blumgart classification | 0.002 | |||
| 1 | 70 | 40 (57.1) | 30 (42.9) | |
| 2 | 29 | 7 (24.1) | 22 (75.9) | |
| 3 | 22 | 6 (27.3) | 16 (72.7) | |
| Bismuth classification | <0.001 | |||
| Left or right duct only | 16 | 13 (81.2) | 3 (18.8) | |
| 1/2 | 41 | 29 (70.7) | 12 (29.3) | |
| 3A/B | 69 | 17 (24.6) | 52 (75.4) | |
| 4 | 19 | 6 (31.6) | 13 (68.4) | |
| Type of resection | 0.001 | |||
| No major hepatectomy | 43 | 29 (67.4) | 14 (32.6) | |
| (Ext.) left hepatectomy | 54 | 23 (42.6) | 31 (57.4) | |
| (Ext.) right hepatectomy | 48 | 13 (27.1) | 35 (72.9) | |
| Caudate lobe resection | 0.129 | |||
| No | 65 | 33 (50.8) | 32 (49.2) | |
| Yes | 80 | 32 (40.0) | 48 (60.0) | |
| PV reconstruction | 0.023 | |||
| No | 118 | 58 (49.2) | 60 (50.8) | |
| Yes | 27 | 7 (25.9) | 20 (74.1) | |
| Blood loss (100 ml), mean (sd) | 22.8 ± 15.4 | 12.5 ± 6.9 | 31.8 ± 15.1 | <0.001 |
| Major post-operative complications (Clavien grade 3 or 4) | 0.002 | |||
| No | 94 | 51 (54.3) | 43 (45.7) | |
| Yes | 50 | 14 (28.0) | 36 (72.0) |
N, number of patients.