Table 3.
Prognostic factors for time to recurrence
| Variable | Est. median time to recurrence (months) | Cox regression |
||||
|---|---|---|---|---|---|---|
| Univariable HR (95% CI) | P-value | Multivariable HR (95% CI) | P-value | |||
| Blood transfusion | No | 44 | Reference | 0.906 | Reference | 0.989 |
| Yes | 39 | 0.97 (0.59–1.59) | 1.00 (0.57–1.78) | |||
| Age | Per year | NA | 0.99 (0.97–1.02) | 0.528 | 1.00 (0.97–1.02) | 0.636 |
| Sex | Female | 61 | Reference | 0.313 | Reference | 0.710 |
| Male | 39 | 1.30 (0.78–2.16) | 1.12 (0.62–2.02) | |||
| Type of resection | No major hepatectomy | 36 | Reference | 0.263 | Reference | 0.656 |
| Major hepatectomy | 44 | 0.75 (0.46–1.24) | 0.88 (0.49–1.57) | |||
| Portal vein reconstruction | No | 40 | Reference | 0.610 | Reference | 0.354 |
| Yes | NAa | 0.61 (0.30–1.24) | 0.69 (0.31–1.52) | |||
| Margin | R0 | 44 | Reference | 0.703 | Reference | 0.392 |
| R1 | 33 | 1.11 (0.65–1.90) | 1.31 (0.71–2.41) | |||
| Lymph node metastasis | N0 | 68 | Reference | <0.001 | Reference | <0.001 |
| N1 | 16 | 3.63 (2.13–6.20) | 3.85 (2.13–6.96) | |||
| Tumor differentiation | Well | Reference | 0.012 | Reference | 0.011 | |
| Moderate/poor | 33 | 2.49 (1.22–5.06) | 2.56 (1.24–5.31) | |||
| Major complications | No | 46 | Reference | 0.118 | Reference | 0.071 |
| Yes | 27 | 1.51 (0.90–2.51) | 1.67 (0.96–2.91) | |||
HR, hazard ratio; CI, confidence interval; NA, not available.
a
The median survival in patients with PV reconstruction is not available, this is because more than half of the patients is alive. The median has not been reached.