Table 5.
Overview of recent studies assessing the effect blood transfusion on overall survival after resection of cholangiocarcinoma
| Author, reference, publication year | N | Type of cholangio-carcinoma | Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|---|---|
| HR or RR (95% CI) | P-value | HR or RR (95% CI) | P-value | |||
| Studies with significant association | ||||||
| Young et al. 201121 | 83 | Perihilar | NA | 0.01 | 2.00 (1.09–3.69) | 0.03 |
| Nagino et al. 201322 | 574 | Perihilar | NA | 0.002 | 1.35 (1.06–1.72) | 0.02 |
| Studies with non-significant association | ||||||
| Muller et al. 201441 | 128 | Any extrahepatic (hilar or distal) | 2.05 (1.19–3.51) | 0.01 | 1.14 (0.52–2.48) | 0.75 |
| Chauhan et al. 201118 | 51 | Hilar | NA | 0.37 | – | |
| Furusuwa et al. 201419 | 144 | Hilar | NA | 0.02 | 1.49 (0.90–2.47) | 0.12 |
| Li et al. 201423 | 58a | Intrahepatic | NA | 0.05 | 1.98 (1.05–3.72) | 0.44 |
| Present study | 145 | Perihilar | 1.18 (0.76–1.83) | 0.46 | 1.00 (0.59–1.68) | 0.99 |
N, number of patients in the study; HR, hazard ratio; RR, relative risk; NA, not available.
a
Perioperative blood transfusion cut off was 600 mL.