Table 1.
Demographic and pharmacokinetic parameters in two groups of patients.
| Measures | Group 1 | Group 2 | Sig. (2-tailed) | |
|---|---|---|---|---|
| Mean ± SD | Mean ± SD | |||
| Number of patients | 10 | 10 | — | |
|
| ||||
| Baseline | Sex (male/female) | 8/2 | 8/2 | 0.61 |
| Age (year) | 48.5 ± 18.3 | 47.7 ± 20.9 | 0.93 | |
| Body weight (kg) | 66.0 ± 12.1 | 73.0 ± 12.2 | 0.24 | |
| Height (cm) | 170.1 ± 9.1 | 171.5 ± 13.9 | 0.78 | |
| APACHE score | 10.6 ± 1.7 | 13.3 ± 1.4 | 0.31 | |
| eGFR (mL/min) | 99.8 ± 49.8 | 112.4 ± 45.7 | 0.58 | |
|
| ||||
| Number of patients | 8 | 10 | — | |
|
| ||||
| Steady state | eGFR (mL/min) | 111.1 ± 57.2 | 113.2 ± 45.9 | 0.93 |
| Total dose (mg/kg) | 44.9 ± 3.8 | 49.4 ± 13.1 | 0.33 | |
| Trough (mg/L) | 14.4 ± 4.3 | 19.4 ± 4.4 | 0.03 | |
| Peak (mg/L) | 28.1 ± 6.0 | 33.7 ± 6.7 | 0.07 | |
| V d (L/kg) | 0.65 ± 0.12 | 0.68 ± 0.10 | 0.61 | |
| Clvanco (mL/min) | 45.1 ± 54.8 | 79.3 ± 53.7 | 0.20 | |
| AUC (mg·hr/L) | 490.7 ± 101.0 | 665.9 ± 136.5 | 0.01 | |
eGFR: estimated glomerular filtration rate, AUC: area under the curve, Cl: clearance, V d: volume of distribution, and Vanco: vancomycin.