Table 3.
Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects under 50 according to sex
| n (%) | OR | 95%CI | P value | |
| Female (n = 17138) | ||||
| Age | 123/17138 (0.7) | 1.08 | 1.04-1.11 | < 0.001 |
| CEA | 123/17138 (0.7) | 1.12 | 1.02-1.23 | 0.023 |
| Male (n = 42644) | ||||
| Age | 441/42644 (1.0) | 1.09 | 1.07-1.10 | < 0.001 |
| Smoking | ||||
| Never/former | 255/29005 (0.9) | Reference | ||
| Current | 186/13639 (1.4) | 1.54 | 1.27-1.87 | < 0.001 |
| CRC family history | ||||
| No | 415/41174 (1.0) | Reference | ||
| Yes | 26/1470 (1.8) | 1.58 | 1.06-2.36 | 0.026 |
| DM-R | ||||
| No | 300/32967 (0.9) | Reference | ||
| Yes | 141/9677 (1.5) | 1.34 | 1.09-1.65 | 0.005 |
| Obesity | ||||
| No | 226/25027 (0.9) | Reference | ||
| Yes | 215/17617 (1.2) | 1.24 | 1.02-1.50 | 0.028 |
| LDL-C | 441/42644 (1.0) | 1.01 | 1.01-1.02 | 0.008 |
| CEA | 441/42644 (1.0) | 1.03 | 1.01-1.05 | 0.014 |
Adjusted for age, sex, smoking, alcohol, obesity (body mass index ≥ 25 kg/m2), abdominal obesity (waist circumference ≥ 90 cm for men or ≥ 85 cm for women), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.