Table 5.
Multivariate analysis of risk factors for the development of advanced colorectal neoplasm in subjects over 50 according to sex
| n (%) | OR | 95%CI | P value | |
| Female (n = 4422) | ||||
| Age | 102/4422 (2.3) | 1.04 | 1.01-1.08 | 0.006 |
| Male (n = 6224) | ||||
| Age | 294/6224 (4.7) | 1.09 | 1.07-1.11 | < 0.001 |
| Smoking | ||||
| Never/former | 188/4410 (4.3) | Reference | ||
| Current | 106/1814 (5.8) | 1.44 | 1.12-1.79 | 0.004 |
| Obesity | ||||
| No | 164/3833 (4.3) | Reference | ||
| Yes | 130/2391 (5.4) | 1.41 | 1.11-1.79 | 0.005 |
| CRC family history | ||||
| No | 281/5796 (4.8) | Reference | ||
| Yes | 13/438 (3.0) | 0.55 | 0.31-0.96 | 0.037 |
| CEA | 294/6224 (4.7) | 1.04 | 1.01-1.08 | 0.023 |
Adjusted for age, smoking, alcohol, obesity (body mass index ≥ 25 kg/m2), triglyceride ≥ 150 mg/dL, HDL-C abnormality (HDL-C < 40 mg/dL for men or < 50 mg/dL for women), LDL-C, DM-R (fasting plasma glucose ≥ 100 mg/dL or hemoglobin A1c ≥ 6.5%, or use of diabetes medications), HTN-R (elevated blood pressure ≥ 130/85 mmHg or use of antihypertensive medications), insulin, regular exercise, CRC family history and CEA. OR: Odds ratio; CI: Confidence interval; CRC: Colorectal cancer; DM-R: Diabetes mellitus-related factors; HTN-R: Hypertension-related factors; CEA: Carcinoembryonic antigen; LDL-C: Low-density lipoprotein-cholesterol; HDL-C: High-density lipoprotein-cholesterol.