Table 1.
Potential molecular targets in schizophrenia.
| Molecular targets proposed for schizophrenia | |
|---|---|
| Target family | Drug actions |
|
| |
| Dopamine receptors | D1 agonists |
| D2 antagonists | |
| D4 antagonists | |
| D4 agonists | |
|
| |
| Serotonin receptors | 5-HT1A agonists |
| 5-HT1A antagonists | |
| 5-HT2A antagonists | |
| 5-HT4 agonists | |
| 5-HT6 agonists | |
| 5-HT7 agonists | |
|
| |
| Muscarinic receptors | M1 agonists |
| M4 agonists | |
| M5 antagonists | |
|
| |
| GABA receptors | GABA.a (α2) agonists |
| GABA.a (α5) antagonists | |
|
| |
| Adrenergic receptors | α2 adrenergic antagonists |
|
| |
| Glutamate receptors | Glycine transporter inhibitors |
| mGluR2/3 agonists | |
| mGluR5 agonists | |
| NMDA enhancers | |
|
| |
| Others | Nicotinic α7 agonists |
| Nicotinic α4β2 agonists | |
| Ampakines | |
| COMT inhibitors | |