Table 2.

Some examples of repurposed drugs for neuropsychiatric disorders.

Drugs (alphabetic order)	Actions/classes	First intervention	New intervention	References
Amantadine	Anticholinergic-like agent	Influenza	Parkinson's disease, ADHD	[6, 7]
Amphotericin B	NSAID∗	Antifungal	Bipolar disorder	[120]
Arbaclofen	GABA agonist	Cerebral palsy	Fragile X syndrome	[116, 121–123]
Atomoxetine	NSRI∗∗	Parkinson's diseases	ADHD	[124]
Dexmecamylamine	Nicotinic receptor modulator	Hypertension	Depression	[125, 126]
Galantamine	Acetylcholinesterase inhibitor	Polio, paralysis	Alzheimer's disease	[127]
Mecamylamine	Nicotinic receptor antagonist	Hypertension	ADHD Depression	[128–131]
Mifepristone	Glucocorticoid receptor type II antagonist	Pregnancy termination	Psychotic major depression, Cushing's syndrome	[132–135]
Ropinirole	D2 agonist	Hypertension	Parkinson's disease, idiopathic restless leg syndrome	[136–138]
Tamoxifen	Estrogen receptor	Breast tumor	Bipolar disorder Mania	[139]
Valsartan	Angiotensin receptor blocker	Hypertension	Alzheimer's disease	[140]

^∗NSAID is nonsteroidal anti-inflammatory drug.

^∗∗NSRI is norepinephrine-selective reuptake inhibitor.