Table 3.

Logistic regression model for significant variations: DA⁺ versus AW controls.

Genetic model Gene/SNP	Additive		Dominant		Recessive
	OR (95% CI)	p Value†	OR (95% CI)	p Value†	OR (95% CI)	p Value*
ADAM33/rs3918396	0.57 (0.08, 4.05)	0.572	0.50 (0.19, 1.30)	0.155	0.63 (0.09, 4.46)	0.645
ADAM33/rs597980	0.88 (0.33, 2.35)	0.799	1.35 (0.63, 2.89)	0.448	0.64 (0.28, 1.44)	0.279
ADAM33/rs2280091	1.63 (0.75, 3.53)†	0.216	1.81 (0.85, 3.87)	0.124	N/A
ALOX5/rs4986832	1.81 (0.30, 10.98)	0.517	1.06 (0.52, 2.18)	0.874	1.82 (0.31, 10.81)	0.512
PTGS1/rs5788	0.54 (0.10, 3.02)	0.479	0.38 (0.17, 0.89)	0.026	0.71 (0.13, 3.77)	0.688
PTGS2/rs20417	5.99 (0.98, 36.57)	0.053	0.99 (0.50, 1.97)	0.969	6.40 (1.06, 38.75)	0.043
PTGS2/rs5277	1.14 (0.54, 2.37)†	0.734	1.02 (0.49, 2.10)	0.963	N/A
GDF15/rs1058587	0.42 (0.06, 2.91)	0.379	0.97 (0.50, 1.86)	0.923	0.41 (0.06, 2.79)	0.365
GDF15/rs1059519	0.94 (0.31, 2.81)	0.907	0.93 (0.48, 1.81)	0.830	0.98 (0.35, 2.74)	0.962
IL10/rs1800896	1.71 (0.67, 4.37)	0.264	0.95 (0.47, 1.93)	0.882	2.04 (0.90, 4.60)	0.087
IL10/rs1800871	0.32 (0.07, 1.40)	0.131	0.58 (0.30, 1.12)	0.105	0.39 (0.09, 1.63)	0.196
IL1α/rs17561	1.47 (0.52, 4.18)	0.470	1.33 (0.69, 2.53)	0.396	1.32 (0.49, 3.60)	0.584
IL1β/rs1143634	0.40 (0.07, 2.33)	0.310	1.34 (0.69, 2.57)	0.387	0.34 (0.06, 1.90)	0.219
IL1β/rs16944	0.75 (0.28, 1.98)	0.557	1.02 (0.53, 1.97)	0.949	0.70 (0.28, 1.74)	0.440
IL1RN/rs419598	0.84 (0.24, 3.01)	0.792	0.96 (0.50, 1.84)	0.901	0.85 (0.24, 2.94)	0.795
TGFB/rs1800469	0.41 (0.14, 1.19)	0.101	0.38 (0.18, 0.74)	0.005	0.64 (0.23, 1.74)	0.380
TGFB/rs1982073	0.77 (0.30, 1.96)	0.581	0.61 (0.30, 1.23)	0.167	1.05 (0.45, 2.44)	0.915
TNFα/rs361525	0.81 (0.25, 2.59)†	0.723	0.59 (0.19, 1.84)	0.364	N/A
TNFα/rs1800629	0.43 (0.05, 4.03)	0.456	2.08 (1.03, 4.17)	0.041	0.34 (0.04, 3.12)	0.341

^*Adjusted for smoking status, duration of exposure and age.

^†Marked SNP, heterozygotes versus major genotype; others, major variant versus minor variant; N/A, no minor genotype.