. Author manuscript; available in PMC: 2016 Mar 31.

Published in final edited form as: J Immunotoxicol. 2015 Sep 4;13(1):119–126. doi: 10.3109/1547691X.2015.1017061

Table 4.

Significant and correlated SNPs with putative regulatory function (RegulomeDB Score 1–3).

Gene	RegulomeDB score	Significant and correlated SNPs	Distance	eQTL	Protein binding	Binding motif
TGFB1	1b	rs1800469^*	0	MGC4093	POLR2A, CREBBP, CTCF	COUPTF
	1f	rs1982072	1378	MGC4093
	2b	rs2241712	3410		NFKB1, CDX2, USF1, SP1, EGR1, ZBTB7A, IRF1, POLR2A, ELF1, GAPBA, SPI1, MAX, NRF1, TBP	SREBP, SREBP1
TNFα	1f	rs1800629^*	0	AIF1		SP1
PTGS2	2b	rs20417^*	0		TFAP2A, TFAP2C	STAT1, E2F-1:DP-1, E2F-1:DP-2, E2F-4:DP-2, EWSR1-FLI1
PTGS1	2b	rs10306141	2085		CTCF, TRIM28, SMC3, RAD21	POU1F1

eQTL, expression quantitative trait loci;

Significant study SNPs.