Figure 4.

Minimal change disease. (A) A photomicrograph showing normal appearing uniform sized glomeruli in the cortex (H&E 400×). (B) A silver stain showing the normal loops with accentuation of the epithelial cells (Jones 400×). (C) A low magnification image of a trichrome stain showing no glomerular or interstitial fibrosis (Trichrome 40×). (D) A negative immunofluorescence panel for immunoglobulins or C3 (Direct immunofluorescence 400×). (E,F) An electron micrograph image showing open capillary loops with effacement of foot processes better visualized in (F), which shows the diffuse fusion of foot processes [6200× (E) and 46,000× (F)].