Table 4.

Association between the change in Global Rating of Change breathing problems and HRQoL

	GRC Breathing Change: T1 to T2
	Worse			Same/Better			Worse vs. Same/Better
PROMISa	Mean Changeb	Cohen’s D Effect Size	SRMc	Mean Changeb	Cohen’s D Effect Size	SRMc	Relative Validityd
Asthma Impact	3.17*	0.44	0.42	−2.06**	−0.19	−0.23	0.50**
Pain Interference	1.66	0.19	0.18	−2.44***	−0.26	−0.32	0.37*
Fatigue	2.90	0.33	0.31	−2.49**	−0.22	−0.26	0.44**
Depressive	0.31			−1.01			0.04NS
Symptoms		0.03	0.04		−0.10	−0.12
Mobility	−2.79*	−0.48	−0.43	1.61**	0.22	0.24	0.55**
Peer Relationships	2.10	0.26	0.29	1.91**	0.22	0.23	<0.01NS
PAQLQa
Symptoms	−0.46*	−0.35	−0.38	0.45***	0.36	0.44	1***
Activity	−0.41	−0.33	−0.32	0.40***	0.31	0.36	0.69***
Emotional	−0.22	−0.17	−0.20	0.40***	0.32	0.40	0.49**
	GRC Breathing Change: T3 to T4
	Worse			Same/Better			Worse vs. Same/Better
PROMISa	Mean Changeb	Cohen’s D Effect Size	SRMc	Mean Changeb	Cohen’s D Effect Size	SRMc	Relative Validityd
Asthma Impact	6.74**	0.60	0.73	−1.07	−0.11	−0.15	0.90***
Pain Interference	0.95	0.08	0.10	−0.90	−0.09	−0.13	0.05NS
Fatigue	0.11	0.01	0.01	−1.60*	−0.15	−0.21	0.04NS
Depressive	2.79			−2.35***			0.31*
Symptoms		0.24	0.26		−0.22	−0.29
Mobility	−2.05	−0.20	−0.23	0.86	0.12	0.12	0.13NS
Peer Relationships	−0.84	−0.10	−0.11	0.57	0.06	0.07	0.02NS
PAQLQa
Symptoms	−0.78*	−0.54	−0.49	0.26***	0.25	0.33	1***
Activity	−0.60	−0.42	−0.47	0.25***	0.25	0.33	0.77***
Emotional	−0.58	−0.39	−0.45	0.18**	0.20	0.28	0.78***

^a: Asthma Impact, Fatigue, Pain Interference, & Depressive Symptoms: higher scores for worse outcomes; other domains: higher scores for better outcomes

^b: Based on paired t-tests

^c: Standardized response mean

^d: PAQLQ domain with the highest significant t-statistic was used to calculate relative validity

^***p<0.001;

^**p<0.01;

^*p<0.05;

NS: non-significant relative validity