Table 5.

Association between the change in Global Rating of Change overall health and HRQoL

	GRC Overall Health Change: T1 to T2
	Worse			Same/Better			Worse vs. Same/Better
PROMISa	Mean Changeb	Cohen’s D Effect Size	SRMc	Mean Changeb	Cohen’s D Effect Size	SRMc	Relative Validityd
Asthma Impact	1.78	0.22	0.24	−1.57*	−0.14	−0.16	0.25NS
Pain Interference	3.11	0.38	0.38	−2.36***	−0.25	−0.30	0.88**
Fatigue	7.53**	0.83	0.87	−2.69***	−0.24	−0.29	2.24***
Depressive	3.47			−1.29*			0.62*
Symptoms		0.31	0.47		−0.13	−0.16
Mobility	−0.68	−0.14	−0.09	1.11*	0.16	0.17	0.12NS
Peer Relationships	−4.47**	−0.50	−0.73	2.66***	0.32	0.32	1.40***
PAQLQa
Symptoms	−0.22	−0.19	−0.17	0.37***	0.30	0.35	0.51*
Activity	−0.38	−0.31	−0.23	0.35***	0.28	0.32	0.72**
Emotional	−0.38	−0.26	−0.30	0.37***	0.32	0.39	1**
	GRC Overall Health Change: T3 to T4
	Worse			Same/Better			Worse vs. Same/Better
PROMISa	Mean Changeb	Cohen’s D Effect Size	SRMc	Mean Changeb	Cohen’s D Effect Size	SRMc	Relative Validityd
Asthma Impact	5.08	0.47	0.44	−0.58	−0.06	−0.08	0.36*
Pain Interference	−2.38	−0.20	−0.22	−0.51	−0.05	−0.07	0.04NS
Fatigue	−2.23	−0.16	−0.23	−1.32*	−0.12	−0.18	0.01NS
Depressive	−2.62			−1.63*			0.01NS
Symptoms		−0.21	−0.21		−0.16	−0.20
Mobility	−1.62	−0.17	−0.14	0.70	0.09	0.10	0.06NS
Peer Relationships	−1.62	−0.18	−0.19	0.59	0.06	0.07	0.04NS
PAQLQa
Symptoms	−0.93	−0.73	−0.57	0.23**	0.22	0.28	1***
Activity	−0.68	−0.59	−0.44	0.22**	0.21	0.29	0.69***
Emotional	−0.78	−0.60	−0.58	0.17**	0.17	0.25	0.99***

^a: Asthma Impact, Fatigue, Pain Interference, & Depressive Symptoms: higher scores for worse outcomes; other domains: higher scores for better outcomes

^b: Based on paired t-tests

^c: Standardized response mean

^d: PAQLQ domain with the highest significant t-statistic was used to calculate relative validity

^***p<0.001;

^**p<0.01;

^*p<0.05;

NS: non-significant relative validity