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(a) Active site of ChoKα1 in complex with compound 10a. Unbiased difference electron density maps are shown at 2.2 σ. (b) Superimposition of 10a with HC-3 (PDB ID: 3G15) and compound 2 (PDB ID: 3ZM9). (c) Residues that stabilize the positive charge of the cationic head in the three superimposed ligands. (d) Residues that undergo the most notable conformational changes when compounds 2 or 10a bind to the choline binding site.
