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. 2016 Mar 23;4(6):e12702. doi: 10.14814/phy2.12702

Figure 7.

Figure 7

Deficiency for NHE1 prevents chronic hypoxia‐induced increases in pH homeostasis in mice. Bar graphs show baseline intracellular pH values measured in (A) KRBS solution (n = 3 for normoxic and n = 4 for hypoxic) and (B) HEPES‐buffered solution (n = 3 each) in PASMCs from normoxic and chronically hypoxic wild‐type (Nhe1 +/+) and NHE1‐deficient (Nhe1 −/−) mice. (C) Bar graphs showing percent actin‐positive vessels in Nhe1 +/+ and Nhe1 −/− mice following exposure to normoxia or chronic hypoxia (n = 3 per group). All bar graphs show mean ± SEM data. *Indicates significant difference from normoxic Nhe1 +/+ value (P < 0.05); †indicates significant difference from hypoxic Nhe1 +/+ value.