Table 3.
Top 10 gene ontology biological processes that were significantly regulated in the frontal cortex
| Groups | Biological processes | # Genes involved | Adjusted P values |
|---|---|---|---|
| Hypoxia (upregulated compared to normoxia) | Immune response | 75 | 1.06E‐27 |
| Defense response | 75 | 4.70E‐27 | |
| Immune system process | 94 | 5.61E‐27 | |
| Response to stress | 115 | 2.48E‐23 | |
| Innate immune response | 50 | 4.83E‐23 | |
| Regulation of immune system process | 60 | 1.20E‐21 | |
| Regulation of immune response | 46 | 4.49E‐19 | |
| Positive regulation of immune system process | 44 | 1.46E‐17 | |
| Regulation of defense response | 39 | 1.79E‐17 | |
| Response to biotic stimulus | 46 | 1.79E‐17 | |
| Hypoxia (downregulated compared to normoxia) | Cellular protein metabolic process | 127 | 4.00E‐04 |
| Protein metabolic process | 140 | 2.80E‐03 | |
| Negative regulation of MAP cascade | 11 | 2.80E‐03 | |
| Negative regulation of ERK1 and ERK2 cascade | 6 | 4.30E‐03 | |
| Negative regulation of intracellular protein kinase cascade | 13 | 8.00E‐03 | |
| Water‐soluble vitamin metabolic process | 9 | 1.09E‐02 | |
| Negative regulation of MAP kinase activity | 9 | 1.09E‐02 | |
| Inactivation of MAPK activity | 6 | 1.09E‐02 | |
| Negative regulation of metabolic process | 61 | 1.27E‐02 | |
| Negative regulation of macromolecule metabolic process | 58 | 1.27E‐02 | |
| Hypoxia + ketamine (upregulated compared to hypoxia without ketamine) | Organelle organization | 97 | 8.50E‐03 |
| Cellular protein metabolic process | 137 | 8.50E‐03 | |
| Response to starvation | 12 | 4.29E‐02 | |
| Cellular metabolic process | 297 | 4.29E‐02 | |
| Protein modification by small protein conjugation or removal | 37 | 4.29E‐02 | |
| Cellular response to starvation | 10 | 5.36E‐02 | |
| Macromolecule modification | 106 | 5.36E‐02 | |
| Protein ubiquitination | 32 | 5.36E‐02 | |
| Cellular protein modification process | 101 | 8.24E‐02 | |
| Protein modification by small protein conjugation or removal | 32 | 8.24E‐02 | |
| Hypoxia + ketamine (downregulated compared to hypoxia without ketamine) | Defense response | 63 | 7.93E‐17 |
| Response to stress | 104 | 3.34E‐15 | |
| Regulation of immune response | 42 | 6.46E‐15 | |
| Immune response | 58 | 9.22E‐15 | |
| Regulation of immune system process | 51 | 3.06E‐14 | |
| Response to wounding | 58 | 3.06E‐14 | |
| Regulation of defense response | 35 | 1.67E‐13 | |
| Immune system process | 74 | 1.70E‐13 | |
| Innate immune response | 39 | 1.70E‐13 | |
| Regulation of response to stress | 45 | 3.20E‐13 |