Table 3. The performance of SVM models developed using various genomic features that include mutant genes, variant genes, CNV, expression, hybrid.

Drug	Mutation	Variation	Expression	CNV	Hybrid	CCLE*
17AAG	0.42	0.55	0.67	0.54	0.76	0.43
AEW541	0.25	0.54	0.69	0.54	0.75	0.33
AZD0530	0.41	0.45	0.65	0.56	0.71	0.19
AZD6244	0.52	0.51	0.81	0.56	0.82	0.59
Erlotinib	0.48	0.56	0.79	0.62	0.82	0.3
Irinotecan	0.58	0.65	0.84	0.56	0.87	0.68
L685458	0.44	0.63	0.82	0.59	0.89	0.48
LBW242	0.44	0.52	0.72	0.52	0.90	0.46
Lapatinib	0.43	0.57	0.75	0.64	0.79	0.09
Nilotinib	0.58	0.53	0.84	0.71	0.77	0.76
Nutlin3	0.24	0.26	0.52	0.33	0.62	0.1
PD0325901	0.54	0.50	0.82	0.55	0.83	0.6
PD0332991	0.42	0.61	0.84	0.51	0.87	0.62
PF2341066	0.38	0.56	0.75	0.61	0.74	0.62
PHA665752	0.37	0.49	0.60	0.49	0.70	0.49
PLX4720	0.68	0.56	0.79	0.68	0.90	0.38
Paclitaxel	0.34	0.51	0.58	0.48	0.73	0.29
Panobinostat	0.46	0.50	0.78	0.58	0.82	0.58
RAF265	0.48	0.49	0.73	0.53	0.78	0.35
Sorafenib	0.37	0.58	0.78	0.44	0.76	0.28
TAE684	0.38	0.42	0.68	0.52	0.74	0.38
TKI258	0.36	0.43	0.72	0.53	0.76	0.3
Topotecan	0.44	0.55	0.75	0.54	0.80	0.58
ZD6474	0.36	0.48	0.71	0.53	0.74	0.22
Average	0.43	0.52	0.73	0.55	0.78	0.42

The performance is given in the form of correlation coefficient between predicted and actual IC₅₀.

^*The performance of models developed in CCLE study.