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. 2016 Mar 31;6:23827. doi: 10.1038/srep23827

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Copyright © 2016, Macmillan Publishers Limited

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mMSCs were pretreated with 10⁻¹⁰ M or 10⁻⁸ M icariin and subsequently induced to differentiate in the presence of Ti particles for 3 days. Icariin maintained ALP activity (A), Runx2 (B) and Osterix (C) gene expression in a dose dependent manner. (D) Icariin maintained OCN expression. Cell differentiation was induced for 10 days. (E,F) Icariin attenuates Ti particle inhibition of mineralization in MSCs. Cell differentiation was induced for 21 days. Data are presented as mean ± SD, *p < 0.05, **p < 0.01, one-way ANOVA and Tukey post-hoc pairwise comparisons.