Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 7;17(6):942–947. doi: 10.4103/1008-682X.150253

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Asian Journal of Andrology

This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.

PMC Copyright notice

PPARγ functions in hypothalamic-pituitary-gonadal axis. Pulsatile GnRH production signals gonadotroph cells in the anterior pituitary to produce FSH and LH that then act on the testis to regulate spermatogenic potential. FSH up-regulates the expression of PPARγ through MAPK signaling pathways while LH inhibits the function of PPARγ via various pathways. High expression of testosterone suppresses the secretion of LH by negative feedback, providing a relatively persistent high-expression of PPARγ. PPARγ: peroxisome proliferator-activated receptor gamma; FSH: follicle-stimulating hormone; LH: luteinizing hormone; MAPK: mitogen-activated protein kinase.