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Immune responses elicited by antigen targeting to DEC-205. Adjuvant-free immunization of mice with antigen-conjugated anti-DEC-205 antibodies leads to regulatory T-cell-dependent tolerance. In contrast, co-injection of an adjuvant with anti-DEC-205 primes a robust cytotoxic T-cell immune response. It also strongly activates a CD4+ T-cell immune response leading to generation of Th cells that support the humoral response.
