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. 2016 Mar 21;5(3):e208. doi: 10.1038/oncsis.2016.17

Figure 2.

Figure 2

Kaiso depletion inhibits breast tumor cell metastasis to the lungs and liver. (a i–vi) Hematoxylin and eosin (H&E) staining of murine lungs and liver revealed that control MDA-231 xenografts formed extensive metastases in lungs (i) and liver (iii), whereas control Hs578T xenografts formed moderate metastases that were limited to the lungs (v) of immune-deficient mice. In contrast, Kaiso-depleted MDA-231 xenografts formed very few metastases in the lungs (ii), and no metastases in the liver (iv) of immune-deficient mice. Kaiso-depleted Hs578T xenografts also formed negligible metastases in the lung (v). (b) H&E images showing extensive metastases of control MDA-231 (i) and control Hs578T (iii) in the lungs of NSG mice after tail vein injections compared with few metastases formed by Kaiso-depleted MDA-231 (ii) and Hs578T cells (iv). Scale bar, 1000 μm. Representative images are shown.