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Pharmacokinetic analysis of erlotinib in Schedule A patients
| 13 | 14 | 15 | 16 | 17 | 18 | |
|---|---|---|---|---|---|---|
| Erlotinib alone (day 6) | ||||||
| AUC (μM) | 23.45 | 29.68 | 45.44 | 46.19 | 13.87 | 50.14 |
| Cmax (μM) | 2.17 | 1.83 | 2.73 | 2.97 | 0.86 | 3.42 |
| Tmax (h) | 6 | 6 | 8 | 8 | 8 | 8 |
| t 1/2 (h) | 7.1 | 25.7 | 18.1 | 15.1 | 15.4 | 9.4 |
| Erlotinib (+rosuvastatin) (day 14) | ||||||
| AUC (μM) | off study | 34.32 | 62.74 | 59.51 | 21.22 | 24.81 |
| Cmax (μM) | off study | 1.96 | 3.95 | 3.90 | 1.19 | 1.57 |
| Tmax (h) | off study | 8 | 6 | 10 | 10 | 8 |
| t1/2 (h) | off study | 24.3 | 14.5 | 12.8 | 12.8 | 13.3 |
