Table 2.

Change in plasma ammonia concentration from baseline to study endpoint in efficacy population

	Episodes n	Mean change in NH3 at endpoint (μmol/L)	Mean time to the endpoint, days
Total	48	-292.2	4.6
Isovaleric aciduria	4	-614.3	2.8
Methylmalonic aciduria	25	-229.2	5.2
Propionic aciduria	19	-307.3	4.2
Neonates	29	-407.6	4.0
Non-neonates	19	-116.1	5.6
With concomitant ammonia scavengers	15	-366.0	3.9
Without concomitant ammonia scavengers/haemofiltration	27	-200.2	5.0
With haemofiltration (with or without ammonia scavengers)	6	-521.8	4.8

NH₃, ammonia