Table 3.

Change in plasma ammonia concentration from baseline to achievement of normalised plasma ammonia^ab

	Episodes n	Mean change at NH3 ≤ 60 μmol/L	Mean time to achieve NH3 ≤ 60 μmol/L, days
Total	42	-272.8	2.4
Isovaleric aciduria	3	-299.0	2.3
Methylmalonic aciduria	20	-233.1	1.9
Propionic aciduria	19	-310.5	3.0
Neonates	24	-392.6	2.0
Non-neonates	18	-113.2	3.1
With concomitant ammonia scavengers	14	-344.7	2.3
Without concomitant ammonia scavengers	22	-157.2	2.8
With haemofiltration (with or without ammonia scavengers)	6	-529.3	1.5

^aNormalised plasma ammonia defined as NH₃ ≤ 60 μmol/L

^bEfficacy population

NH₃, ammonia