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. 2016 Mar 31;9:181. doi: 10.1186/s13071-016-1464-y

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© Moreira et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Relative weight of the liver of uninfected hamsters as a control group (C, n = 10 animals/time; white) and hamsters experimentally infected with L. infantum (PP75 or OP46 strain) by routes of inoculation: intradermal (ID, n = 10 animals/time; light gray), intraperitoneal (IP, n = 10 animals/time; dark gray), or intracardiac (IC, n = 10 animals/time; black) after 1, 3, 6, and 9 months of infection. The results are expressed as mean ± standard deviation. Significant differences (P < 0.05) between infection with the different routes of inoculation are represented by the connected lines (a). Macroscopic changes in the liver of uninfected hamsters as a control group (C; white) and in hamsters experimentally infected with L. infantum (PP75 or OP46) by the IC route of inoculation at 9 months of infection. The liver of control hamsters with a normal appearance; liver of hamsters infected with strains PP75 and OP46 appeared friable; changed color from red to pale yellowish brown (b). Correlation between parasite load and relative weight of the liver in hamsters experimentally infected with L. infantum (PP75 or OP46 strain) by routes of inoculation: intraperitoneal (IP; dark gray) or intracardiac (IC; black) after 1, 3, 6 and 9 months of infection. Spearman’s correlation index r and P-values are shown on the graphs; the connecting lines illustrate positive and negative correlation indices (c)