Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 31;9:181. doi: 10.1186/s13071-016-1464-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Moreira et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Relative weight of the spleen in uninfected hamsters as a control group (C, n = 10 animals/time; white) and hamsters experimentally infected with L. infantum (PP75 or OP46 strain) by routes of inoculation: intradermal (ID, n = 10 animals/time; light gray), intraperitoneal (IP, n = 10 animals/time; dark gray), or intracardiac (IC, n = 10 animals/time; black) after 1, 3, 6 and 9 months of infection. The results are expressed as mean ± standard deviation. Significant differences (P < 0.05) between infection with the different routes of inoculation are represented by the connected lines (a). Macroscopic changes in the spleen of uninfected hamsters as a control group (C) and in hamsters experimentally infected with L. infantum (PP75 or OP46 strain) by the IC route of inoculation at 9 months of infection. The macroscopic splenic changes included increase in the volume of the organ (splenomegaly), thickening of edges, rugose and irregular surface and dark coloration (b). Correlation between parasite load and relative weight in the spleen of hamsters experimentally infected with L. infantum (PP75 or OP46 strain) by different routes of inoculation: intraperitoneal (IP; dark gray) or intracardiac (IC; black) after 1, 3, 6 and 9 months of infection. Spearman’s correlation index r and P-values are shown on the graphs; the connecting lines illustrate positive and negative correlation indices (c)