Table 1.
Clinicopathological analysis of hamsters experimentally infected with L. infantum. Absolute (n) and percentage (%)
| Time/infection (months) | Clinical signs | Experimental groups, n (%) | |||||
|---|---|---|---|---|---|---|---|
| MHOM/BR/74/PP75 strain | MCAN/BR/2008/OP46 strain | ||||||
| ID | IP | IC | ID | IP | IC | ||
| 1 | – | – | – | – | – | – | – |
| 3 | Splenomegaly | – | 1/10 (10) | – | – | 1/10 (10) | 8/10 (80) |
| Ascites | – | 1/10 (10) | – | 6/10 (60) | 1/10 (10) | – | |
| 6 | Splenomegaly | – | – | 2/10 (20) | 1/10 (10) | 7/10 (70) | 10/10 (100) |
| Hepatomegaly | 1/10 (10) | – | – | – | – | 1/10 (10) | |
| Ascites | 4/10 (40) | 4/10 (40) | 3/10 (30) | 4/10 (40) | 1/10 (10) | 6/10 (60) | |
| Emaciationa | – | – | – | 1/10 (10) | – | 9/10 (90) | |
| 9 | Splenomegaly | 1/10 (10) | – | 7/9 (77) | 1/10 (10) | 7/8 (87) | 6/6 (100) |
| Hepatomegaly | – | – | 3/9 (33) | 1/10 (10) | – | 1/6 (16) | |
| Ascites | 1/10 (10) | – | 1/9 (11) | – | 3/8 (37) | 6/6 (100) | |
| Emaciationb | – | – | 2/9 (22) | – | – | 6/6 (100) | |
| Skin lesion | – | – | – | – | – | 6/6 (100) | |
| Swelling of the paw | – | – | – | – | – | 6/6 (100) | |
Animals were infected with PP75 and OP46 strains of L. infantum by different routes of inoculation: intradermal (ID), intraperitoneal (IP), and intracardiac (IC)
aWeight loss with preservation of the general condition of the animal
bAccentuated/cachexia weight loss (observed only in the group inoculated by the IC route)