Table 2.
Erythrogram of control hamsters and hamsters experimentally infected with strains PP75 and OP46 of L. infantum
| Hematological variables by group | Time/months | |||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 6 | 9 | 1 | 3 | 6 | 9 | |
| C group | ||||||||
| Erythrocytes (106/mm3) | 7.2 ± 0.3 | 7.2 ± 1.1 | 8.5 ± 1.2 | 8.4 ± 1.0 | 7.4 ± 0.4 | 7.0 ± 0.3 | 7.1 ± 0.2 | 6.7 ± 0.3 |
| Hemoglobin (g/dL) | 13.9 ± 0.6 | 13.5 ± 0.8 | 17.6 ± 2.1 | 17.5 ± 2.3 | 15.0 ± 1.0 | 13.3 ± 0.9 | 13.3 ± 0.5 | 13.2 ± 0.7 |
| Hematocrit (%) | 35.5 ± 3.6 | 34.6 ± 7.2 | 39.5 ± 5.5 | 38.4 ± 6.7 | 32.6 ± 1.5 | 30.5 ± 2.3 | 32.5 ± 2.3 | 33.2 ± 2.0 |
| Platelets (106/mm3) | 165.8 ± 37.4 | 142.6 ± 33.8 | 154.9 ± 143 | 127.4 ± 12.5 | 139.9 ± 20.8 | 136.4 ± 16.9 | 164.7 ± 15.5 | 174.0 ± 20.5 |
| Strain/months after infection | ||||||||
| PP75 strain | OP46 strain | |||||||
| 1 | 3 | 6 | 9 | 1 | 3 | 6 | 9 | |
| ID group | ||||||||
| Erythrocytes (106/mm3) | 6.5 ± 0.4 | 7.2 ± 0.2 | 6.5 ± 0.4a | 8.5 ± 0.7 | 7.4 ± 0.3 | 6.8 ± 0.3 | 6.7 ± 0.8 | 6.9 ± 0.3 |
| Hemoglobin (g/dL) | 13.7 ± 1.1 | 13.6 ± 0.5 | 12.7 ± 1.0a | 19.7 ± 4.5 | 15.2 ± 0.6 | 13.3 ± 0.7 | 12.6 ± 1.6 | 13.7 ± 0.3 |
| Hematocrit (%) | 29.3 ± 2.1a | 36.3 ± 3.0 | 31.1 ± 2.7a | 38.3 ± 3.9 | 33.9 ± 1.5 | 31.2 ± 3.0 | 33.6 ± 3.6 | 34.0 ± 2.0 |
| Platelets (106/mm3) | 123.8 ± 16.2 | 168.70 ± 25.26 | 138.3 ± 19.2 | 108.1 ± 18.0 | 156.8 ± 27.5 | 141.1 ± 24.4 | 185.5 ± 24.4 | 189.4 ± 27.3 |
| IP group | ||||||||
| Erythrocytes (106/mm3) | 6.1 ± 0.1 | 6.8 ± 0.7 | 6.7 ± 0.2a | 9.8 ± 0.5a,b | 7.5 ± 1.0 | 7.1 ± 0.4 | 7.0 ± 0.5 | 6.2 ± 1.0 |
| Hemoglobin (g/dL) | 13.4 ± 0.5 | 13.1 ± 1.2 | 13.4 ± 0.4a | 21.2 ± 1.3 | 14.4 ± 0.6 | 13.6 ± 1.2 | 12.8 ± 1.1 | 12.0 ± 2.0 |
| Hematocrit (%) | 28.9 ± 1.5a | 38.7 ± 3.2 | 31.2 ± 2.7a | 43.9 ± 2.2 | 32.0 ± 2.6 | 31.4 ± 3.2 | 36.1 ± 2.6 | 31.0 ± 4.2 |
| Platelets (106/mm3) | 134.1 ± 45.3 | 221.6 ± 75.0a | 132.2 ± 23.4 | 126.3 ± 14.5 | 169.3 ± 35.4 | 145.6 ± 32.1 | 184.4 ± 32.7 | 174.6 ± 87.4 |
| IC group | ||||||||
| Erythrocytes (106/mm3) | 6.6 ± 0.4 | 7.2 ± 0.7 | 6.8 ± 0.3a | 9.2 ± 1.0 | 7.1 ± 0.4 | 6.7 ± 0.3 | 4.3 ± 1.4a,b,c | 4.7 ± 1.9a,b, c |
| Hemoglobin (g/dL) | 13.7 ± 0.8 | 13.8 ± 1.2 | 13.6 ± 0.7a | 20.0 ± 2.4 | 14.5 ± 0.9 | 12.3 ± 1.6 | 7.0 ± 1.8a,b,c | 10.1 ± 4.2a,b |
| Hematocrit (%) | 30.1 ± 1.8a | 35.0 ± 3.6 | 31.5 ± 2.4a | 41.5 ± 4.3 | 31.6 ± 2.1 | 29.0 ± 4.4 | 21.0 ± 6.9a,b,c | 25.0 ± 9.4a,b |
| Platelets (106/mm3) | 134.1 ± 21.5 | 144.6 ± 22.3c | 135.4 ± 13.5 | 108.5 ± 17.5 | 156.5 ± 17.0 | 110.9 ± 29.8 | 329.4 ± 153.5a,b,c | 291.3 ± 136.4a,b,c |
Values (mean ± standard deviation) erytrogram of uninfected hamsters as a control group (C) and infected animals with strains PP75 and OP46 of L. infantum by different routes of inoculation: intradermal (ID), intraperitoneal (IP), intracardiac (IC). Significant differences (P < 0.05) are represented by letters a, b, crelated to the C, ID and IP groups respectively