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. 2016 Mar 31;16:24. doi: 10.1186/s12935-016-0299-0

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© Pera et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Ca_v3.2 upregulation in trastuzumab-resistant cell lines. a Assessment of mRNA levels of 44 calcium pumps, channels and calcium regulating proteins identified increased expression of Ca_v3.2 in three of four trastuzumab resistant cell lines. All values were measured relative to 18 S rRNA and expressed as −ΔC_T. Data points at Y = −20 represent no mRNA detection (n = 3 ± SD). b Acquired resistant cell line RT₁ and both intrinsic resistant cell lines (RV₁, RV₂) showed significantly increased expression of Ca_v3.2 compared to trastuzumab sensitive age-matched control (SV₁) (n = 3 ± SD). Statistical analyses were performed using one-way ANOVA with Bonferroni post-tests (*p ≤ 0.05, **p ≤ 0.01)