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. 2016 Mar 31;16:24. doi: 10.1186/s12935-016-0299-0

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© Pera et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Intracellular calcium measurements with ATP stimulation in trastuzumab-sensitive and resistant cell lines. a Example of relative cytosolic calcium [Ca²⁺]_CYT responses after ATP [1 mM] stimulation in trastuzumab-sensitive age-matched controls (SV₁, SV₂), acquired resistant cell lines (RT₁, RT₂) and intrinsic resistant cell lines (RV₁, RV₂). b Relative calcium [Ca²⁺]_CYT responses at 800 s with ATP stimulation [1 nM to 1 mM] in aged-matched control and resistant cell lines (n = 3 ± SD). Acquired resistant cell lines (RT₁, RT₂) showed a slower recovery after ATP stimulation with a significant higher relative calcium [Ca²⁺]_CYT level at 800 s while intrinsic resistant cell lines (RV₁, RV₂,) showed similar recovery rate and similar relative calcium [Ca²⁺]_CYT levels compared to aged matched control SV₁. Statistical analysis was performed using two-way ANOVA with Bonferroni post-tests, compared to SV₁ (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001)