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. 2016 Mar 31;16:24. doi: 10.1186/s12935-016-0299-0

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© Pera et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effect of CACNA1H (Ca_v3.2) overexpression on expression of mRNA markers associated with tumour progression and drug-resistance. SKBR3 parental cells were co-transfected with α1Ha + pEGFP-N1 (EGFP Ca_v3.2) or pCDNA3.1 + pEGFP-N1 (EGFP MOCK) and sorted into EGFP enriched and depleted populations 24 h after transfection. Results are expressed as fold change normalised to EGFP MOCK. EGFP Ca_v3.2 cells showed an approximate greater than 2 10⁶ fold increase in expression compared to EGFP MOCK cells (n = 3 ±SD). Overexpression of Ca_v3.2 did not increase levels of markers associated with EMT (vimentin, snail), basal markers (KR5, KR6A ) and markers associated with drug-resistance (CXCR4, FOXM1, HSP90AA1) (n = 3 ±SD)