Table 2.
Clinical and parasitological responses
| Study site | Total | Myitkyina | Thabeikkyin | P value |
|---|---|---|---|---|
| Median time of fever clearance (IQR), hours | 6 (6–12) | 6 (6–6) | 12 (6–18) | 0.008** |
| Median parasite clearance Half-life (IQR), hours | 3.3 (2.1–4.8) | 4.4 (3.4–6.7) | 2.6 (2.0–3.8) | <0.0001** |
| Parasite clearance time (Median, IQR), hours | 42 (30–72) | 72 (42–96) | 36 (24–72) | <0.0001** |
| Parasite clearance Half-life >4 h, n/N (%) | 42/114 (37.7) | 27/43 (62.8) | 16/71 (22.5) | P < 0.001* |
| Parasite clearance half-life >5 h, n/N (%) | 26/114 (22.8) | 17/43 (39.5) | 9/71 (12.7) | P < 0.01* |
| Day 3 parasitaemia, n/N (%) | 20/114 (17.5) | 13/43 (30.2) | 7/71 (9.9) | P < 0.01* |
| Gametocyte carriage time (median, IQR), hours | 18 (9–57) | 57 (6–81) | 16.5 (12–24) | 0.31 |
| ACPR on day 42, % (95 % CI) | 100 (97–100) | 100 (92–100) | 100 (95–100) |
ACPR adequate clinical and parasitological response
* Chi square statistics
** Mann–Whitney test