Skip to main content
. 2016 Mar 31;7:76. doi: 10.3389/fphar.2016.00076

FIGURE 2.

FIGURE 2

Scheme of the simultaneous binding of bivalent ligands with linkers of appropriate length to two receptors in a GPCR dimer. The agonist/antagonist moieties of the bivalent ligand are selective for their respective receptors (orange for GPCR-I, green for GPCR-II) and are linked by an spacer. (A) Binding to two equal GPCRs forming an homodimer. (B) Binding to two different GPCRs forming an heterodimer. A full account of the possibilities of binding of bivalent ligands to GPCRs is provided by Brogi et al. (2014).