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. 2016 Mar 30;17:58. doi: 10.1186/s13059-016-0901-8

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© Wang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Therapeutic treatment of miR-223 antagomirs in TNBS-induced colitis mice. a Recovery of body weight in mice with colitis by miR-223 antagomirs. Control: colitis mice treated with ethanol; TNBS + Anti-miR: colitis mice treated with antagomir223; TNBS + Anti-CTL: colitis mice treated with an isotype control of antagomir223. ***P <0.001 for comparison between the TNBS + Anti-CTL group and the Ethanol Control group; ^# P <0.05, ^## P <0.01, ^### P <0.001 for the statistical significance between the TNBS + Anti-miR group and the TNBS + anti-CTL group. b Representative images of the colon (H&E staining). c Serum FITC-dextran was quantified as a measure of intestinal permeability. d-f Antagomir223 upregulates CLDN8