Table 1.

Approximate Computational Cost Associated With Each Solvent Model Relative to the Cost of a Vacuum Calculation for Simulations of Src SH2 Domain

Solvent model	ns/daya	Cost relative to vacuuma
Vacuum	91.1	1
TIP3P	3.82	∼23.8b
GBMV II	13.93	∼6.5
FACTS	26.44	∼3.4
SCPISM	60.75	∼1.5

^aCalculated using two 8‐core Intel Xeon‐E5 processors, totaling 16 cores.

^bSimulation box contains the SH2 domain and 6840 water molecules.