Figure 2.

Schematic representation of (A) 1D and (B) 2D EDS‐HREM methods. (A) In the 1D EDS‐HREM, the baseline Hamiltonian that follows the minimum of initial end state Hamiltonians is coupled with smoothed Hamiltonians. (B) In the 2D EDS‐HREM, replica exchanges are performed between different pH conditions.